Tranexamic acid, identified by CAS NO. 1197 - 18 - 8, is a well - known synthetic amino acid with significant antifibrinolytic properties. It plays a crucial role in various medical and cosmetic applications. As a trusted supplier of Tranexamic acid, I am here to share comprehensive information about how it is administered.
1. Medical Administration
Oral Administration
In the medical field, oral administration of tranexamic acid is a common approach, especially for treating conditions such as heavy menstrual bleeding. The tablets are usually taken with water, and the dosage is determined based on the patient's condition. For instance, in cases of menorrhagia, the typical adult dose might range from 1 - 1.5 grams taken three to four times a day during menstruation. This form of administration is convenient for patients as it can be self - managed at home. However, it is important to take it with or after meals to reduce the risk of gastrointestinal side effects like nausea, vomiting, or diarrhea.
The mechanism behind oral tranexamic acid is that it gets absorbed through the gastrointestinal tract into the bloodstream. Once in the bloodstream, it reaches the target tissues and inhibits the activation of plasminogen to plasmin. Plasmin is an enzyme that breaks down blood clots. By inhibiting its formation, tranexamic acid helps to maintain the integrity of blood clots, thereby reducing excessive bleeding.
Intravenous Administration
Intravenous (IV) administration of tranexamic acid is used in more critical situations, such as during surgeries or in cases of severe bleeding. This method allows for a rapid onset of action as the drug is directly introduced into the bloodstream. In surgical settings, it can be given as a bolus injection at the beginning of the procedure or as a continuous infusion.
The dosage for IV administration also depends on the type of surgery and the patient's body weight. For example, in cardiac surgeries, a loading dose of 10 - 20 mg/kg might be given as a bolus, followed by a continuous infusion of 1 - 2 mg/kg per hour. The advantage of IV administration is that it can quickly achieve high plasma concentrations of the drug, which is essential for controlling acute bleeding. However, it requires trained medical personnel to administer and close monitoring of the patient's vital signs during the process to detect any potential adverse reactions such as allergic reactions or changes in blood pressure.
Intramuscular Administration
Although less common than oral or IV administration, intramuscular (IM) injection of tranexamic acid can also be used. This method is suitable for situations where IV access is difficult to obtain but a faster onset of action than oral administration is required. The drug is injected into a large muscle, such as the gluteus maximus or the deltoid muscle.
The dosage for IM administration is similar to that of oral administration in some cases, but it is adjusted according to the patient's condition. However, IM injection can be painful for the patient, and there is a risk of local tissue irritation at the injection site.
2. Cosmetic Administration
Topical Application
In the cosmetic industry, tranexamic acid is often used in topical formulations such as creams, serums, and lotions. These products are mainly used for skin - lightening purposes. Tranexamic acid inhibits the activity of tyrosinase, an enzyme involved in the production of melanin. By reducing melanin synthesis, it helps to fade dark spots, melasma, and other hyperpigmentation issues.
When using topical tranexamic acid products, it is recommended to apply a small amount to clean, dry skin and gently massage it in until fully absorbed. It is usually applied once or twice a day, preferably in the evening as the skin's repair process is more active during sleep. Some products may contain other active ingredients such as Hydroxypinacolone Retinoate ; CAS NO.: 893412 - 73 - 2 or Ascorbyl Tetraisopalmitate (VCIP) ; CAS NO.: 183476 - 82 - 6 to enhance the skin - lightening effect.
However, it is important to note that topical tranexamic acid may cause skin irritation in some individuals, especially those with sensitive skin. Therefore, it is advisable to perform a patch test before using the product on a larger area of the skin.
3. Factors Affecting Administration
Patient's Health Status
The patient's overall health status is a crucial factor in determining the appropriate method and dosage of tranexamic acid administration. For example, patients with kidney problems may have impaired drug clearance. In such cases, the dosage may need to be adjusted to avoid drug accumulation in the body. Similarly, patients with a history of thromboembolic events may require careful consideration before using tranexamic acid as it can potentially increase the risk of blood clots.
Drug Interactions
Tranexamic acid can interact with other drugs. For instance, it should not be used concurrently with certain thrombolytic agents as this can lead to an increased risk of thrombosis. Also, drugs that affect the liver or kidney function may influence the metabolism and excretion of tranexamic acid. Therefore, it is essential for healthcare providers to review the patient's medication history before prescribing tranexamic acid.
4. Our Offer as a Supplier
As a leading supplier of Tranexamic acid (CAS NO. 1197 - 18 - 8), we ensure the highest quality of our product. Our tranexamic acid is produced under strict quality control standards, meeting all relevant regulatory requirements. We offer a range of forms, including powder for different formulations, whether it is for medical or cosmetic use.
In addition to Tranexamic acid, we also supply other high - quality cosmetic raw materials such as Prunin；CAS NO.529 - 55 - 5, which has various beneficial effects on the skin. Our team of experts is always ready to provide technical support and guidance on the use and formulation of these products.
If you are interested in purchasing Tranexamic acid or any of our other products, we invite you to contact us for procurement discussions. We are committed to providing you with the best products and services to meet your specific needs.
References
- "Tranexamic acid: a review of its use in surgery and other clinical settings." Journal of Blood Medicine.
- "The use of tranexamic acid in the treatment of menorrhagia." Obstetrics and Gynecology Clinics of North America.
- "Topical tranexamic acid for the treatment of melasma: a review." Dermatologic Therapy.