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CALCIUML-5-METHYLTETRAHYDROFOLATE

CAS NO.: 151533-22-1
EINECS: 691-636-3
Synonyms:Levomefolate calcium ；(S) -2 - (4- ((((S) -2 - amino-5-Methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)amino)benzamido)pentanedioic acid, calciuM salt; L-5- Methyl leucovorin; Calcium (S)-2-(4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino
MF: C20H23CaN7O6
MW: 497.53
Melting Point:300°C min

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Description

Character

White to light yellowish powder, soluble in Aqueous Acid (Heated), slight soluble in water(Heated)

Items		Specifications
Appearance		White to light yellowish powder
Identification	IR	A. The IR spectrum of the sample correspends to that of the Refenence standard.
	HPLC	B. The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of Standard preparation, as obtained in the Assay.
	Calcium salt	positive.
Calcium (on dry basis)		7.0%-8.5%
Water		6.0%-17.0%
Heavy metals		≤20 ppm
Chloride		≤0.5%
Boron		≤50mg/kg
Platinum		≤10μmg/kg
Arsenic		≤1.5mg/kg
Cadmium		≤0.5mg/kg
Lead		≤1.0mg/kg
Mercury		≤1.5mg/kg
D-5-Methylfolate		≤1.0%
Ethanol		≤5000ppm
2-Propanol		≤5000ppm
Total Plate Count		≤1000 cfu/g
Yeast & Mold		≤100 cfu/g
Salmonella		Absent
E. Coli.		Absent
Staphylococcus aureus		Absent
Pseudomonas aeruginosa		Absent
Candida albicans		Absent
Clostridia		Absent
Related Substances		a/ 4-Aminobenzoyl-glutamic acid ≤0.5%
		b/4a-Hydroxy-5-methyl-tetrahydrofolic acid≤1.0%
		c+d/ The sum of 6S-and 6R-Mefox≤1.0%
		e/ Tetrahydrofolic acid ≤ 0.5%
		f/7,8-Dihydrofolic acid ≤0.5%
		g/ Folic acid ≤0.5%
		h/ 5,10-Methylenete-trahydrofolic acid ≤ 0.5%
		i/5-Methyltetrahydrop-teroic acid ≤0.5%
		j/ Dimethylte-trahydrofolic acid ≤ 0.15%
		Total Impurities ≤2.5%
Assay on anhydrous basis		95.0%-102.0%

Product Introduction

Application field	Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects. Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor. As adjuvant therapy for colon cancer, rectal cancer. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer. For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued.
Product Brief	CALCIUML-5-METHYLTETRAHYDROFOLATE also called Calcium L-5-methyltetrahydrofolate belongs to the folic acid family of vitamins (vitamin B9, folic acid), which is a coenzyme form of folic acid. Calcium L-5-methyltetrahydrofolate (5-mthf) is a salt-forming methyl derivative form naturally produced by folic acid. 5-mthf is also known as L-methylfolate. It is the most biologically active and functional folic acid. In calcium salt form, it is easier to absorb than ordinary folic acid. Levomefolate calcium is a stable salt of the naturally occurring form of folates and is the predominant folate form in foods.
Package	1kg/Aluminium Foil Bag, or as per client's requirement
Storage conditions	2-8°C;Store in originally sealed packaging in a cool and dry place
Shelf life	2 years

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Our products are formulated to meet the needs of all skin types.

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Our ingredients are formulated to be compatible with different pH levels.

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Our products are thoroughly tested and inspected before leaving the factory.

We always adhere to the principle of efficiency first and take the path of high quality development.

FAQ

Q: What is the benefit of CALCIUML-5-METHYLTETRAHYDROFOLATE

A: CALCIUML - 5 - METHYLTETRAHYDROFOLATE is the calcium salt of 5-methyltetrahydro folic acid, a biologically active form of folic acid that functions, in conjunction with Vitamin B12, as a methyl-group donor involved in the conversion of homocysteine to methionine.The availability of methyl groups is essential for a variety of methylation reactions including the synthesis of DNA and proper neural tube closure. Levomefolate is included in formulations of certain oral contraceptives to ensure adequate folic acid levels in women of child-bearing age to reduce the risk of neural tube defects. The combination of levomefolate and oral contraceptives increases folic acid levels.

Q: Where is CALCIUML-5-METHYLTETRAHYDROFOLATE found

A: The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid.

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