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BETA-nicotinamide Mononucleotide, Reduced Form, Disodium Salt (NMNH)
CAS NO.: 108347-85-9
Synonyms: β-nicotinamide mononucleotide, reduced
form, disodium salt(NMNH); NMNH β-nicotinamide mononucleotide, reduced form, disodium salt; NMNH;β-nicotinamide mononucleotide, reduced form, disodium salt; β-Nicotinamide mononucleotide, reduced form;NMNH(β-Nicotinamide mononucleotide Reduced); β-nicotinamide mononucleotide , reducedform,disodiumsalt; β-Nicotinamide mononucleotide Reduced
MF: C11H18N2NaO8P
MW: 360.23
Description
Character
light yellow to yellow powder, odorless, soluble in water
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Test Item |
Specifications |
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Appearance |
Yellow powder |
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Appearance of 5% solution |
Faint yellow |
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pH value |
7-10 |
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Water content(by Karl Fisher) |
≤5% |
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Purity (HPLC) |
≥98% |
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Contents(dry basis) |
≥98% |
Product Introduction
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Application field |
NMNH (reduced Nicotinamide Mononucleotide) is a new potent NAD+ precursor. It is a new form of NMN, can increase NAD levels to a much higher extent.NMNH is a fluorescent molecule, in contrast to NMN. The molecular formulae for NMNH is C11H17N2O8P and it is also known as 1-(5-O-phosphono-beta-D-ribofuranosyl) -1,4 - dihydropyridine -3- carboxamide Reduced nicotinamide mononucleotide. |
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Product Brief |
β-nicotinamide mononucleotide, reduced form, disodium salt (NMNH)is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMNH is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra. β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate NMNH, which is subsequently converted to NAD+ by adenyltransferase.At 50-100 μM, NMNH has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels. |
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Package |
1kg/aluminium foil bag, or as per client's requirement |
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Storage conditions |
2-8°C;Store in originally sealed packaging in a cool and dry place |
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Shelf life |
2 years |
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