The conclusion first: No. At least not now.
This question is probably the most frequently asked in NAD⁺-related searches. The underlying message is: I want to stay up all night, but I don't want to bear the consequences; I want to succeed effortlessly, but I don't want to pay the price.
I understand this desire. But science can't make that promise.
I. Staying up all night without ruining your face? Animals have hope, humans are still a long way off.
Let's start with the "no-skin-ruining" part.
Indeed, a 2024 animal study found that NAD⁺ supplementation can alleviate cognitive impairment and memory decline in mice with chronic sleep deprivation, and can also inhibit the inflammatory response of microglia. Simply put: In mice, NAD⁺ supplementation can indeed reduce brain damage caused by sleep deprivation. (Article cited from the journal *Brain*: Neuronal death induced by misfolded prion protein is due to NAD⁺ depletion and can be relieved in vitro and in vivo by NAD⁺ replenishment.)
But note two key words: mice and chronic sleep deprivation.
You are not a mouse. You are not a subject forced to move for 18 hours on a rotating rod. You simply stayed up until 2 AM watching TV last night and want to make up for the loss with a capsule today. The significance of animal experiments lies in "providing direction," not "prescribing a solution for humans."
II. NAD⁺ does affect sleep, but it affects "repair," not "offset."
The relationship between NAD⁺ and sleep is real.
Mechanistically, NAD⁺ participates in the regulation of circadian rhythms by activating SIRT1 to regulate the expression of circadian clock genes (BMAL1 and PER2). A Norwegian clinical trial, NADream, scheduled to begin in 2025, is attempting to verify whether supplementing with NR (a precursor to NAD⁺) can improve sleep quality in healthy adults by restoring mitochondrial efficiency and reducing oxidative stress. Furthermore, a 2025 review published in *Nutrients* summarized 11 studies and found that NR supplementation can:
- Increase REM sleep by approximately 17% in mice
- Improve sleep efficiency in young and middle-aged men with insomnia
- Reduce fatigue and drowsiness in the elderly
However, please note: these studies refer to "improving sleep quality in people with existing sleep problems," not "making you feel fully refreshed after staying up all night." The former is repair, the latter is offset-they are worlds apart.
III. What is Inward selling? It sells "raw materials," not "myths."
You might ask, "Since you're being so conservative, why does Invertin also produce NAD⁺?"
Because Inward sells high-quality raw materials-injection-grade lyophilized powder and food-grade raw materials for medical institutions, research institutes, and pharmaceutical companies. The company focuses on making its products the best they can be: 100% β-crystalline, endotoxin-free, reconstituted in seconds, and compliant with cGMP standards.
However, we do not encourage healthy individuals to undergo "anti-aging IV drips," nor will we sell injectable products to individual users. The decision to pull the trigger always rests with the doctor and patient in a joint, evidence-based decision.
In conclusion
Back to the initial question: Can NAD⁺ prevent my skin from sagging and keep me looking 20 despite staying up late?
The answer has three layers:
- If you expect it to undo the damage from staying up late: It cannot undo it, but it can repair it.
- If you have a clear sleep problem: NAD⁺ precursors (NR/NMN) can help to some extent, but the effects vary from person to person.
- If you want to "anti-age" through injections: There is evidence, but the effects are not as good as you might expect.
